Control engineering and synthetic biology: working in synergy for the analysis and control of microbial systems

Giansimone Perrino, Andreas Hadjimitsis, Rodrigo Ledesma-Amaro, Guy-Bart Stan

Department of Bioengineering & Imperial College Centre for Synthetic Biology, Imperial College London, UK.

Abstract

The implementation of novel functionalities in living cells is a key aspect of synthetic biology. In the last decade, the field of synthetic biology has made progress working in synergy with control engineering, whose solid framework has provided concepts and tools to analyse biological systems and guide their design. In this review, we briefly highlight recent work focused on the application of control theoretical concepts and tools for the analysis and design of synthetic biology systems in microbial cells.